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                            July 8, 2021

       Tillman U. Gerngross, Ph.D.
       Chief Executive Officer
       Adagio Therapeutics, Inc.
       303 Wyman Street, Suite 300
       Waltham, MA 02451

                                                        Re: Adagio
Therapeutics, Inc.
                                                            Amendment No. 1 to
Draft Registration Statement on Form S-1
                                                            Submitted June 28,
                                                            CIK No. 0001832038

       Dear Dr. Gerngross:

             We have reviewed your amended draft registration statement and
have the following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by providing the requested
information and either submitting
       an amended draft registration statement or publicly filing your
registration statement on
       EDGAR. If you do not believe our comments apply to your facts and
circumstances or do not
       believe an amendment is appropriate, please tell us why in your

              After reviewing the information you provide in response to these
comments and your
       amended draft registration statement or filed registration statement, we
may have additional
       comments. Unless we note otherwise, our references to prior comments are
to comments in our
       June 16, 2021 letter.

       Amendment No. 1 to Draft Registration Statement

       Prospectus Summary, page 1

   1.                                                   We reissue prior
comment 1 to the extent you continue to characterize ADG20 as having
                                                        demonstrated an ability
to "potently neutralize" SARS-CoV-2.
   2.                                                   We reissue comment 2 to
the extent that replacing "rapid" with "near term" on pages 4 and
                                                        5 did not provide the
clarification we requested in our comment.
 Tillman U. Gerngross, Ph.D.
FirstName   LastNameTillman U. Gerngross, Ph.D.
Adagio Therapeutics, Inc.
July 8, 2021NameAdagio Therapeutics, Inc.
July 8,2 2021 Page 2
FirstName LastName
       You may contact Tara Harkins at (202) 551-3639 or Al Pavot at (202)
551-3738 if you
have questions regarding the financial statements and related matters. Please
contact Abby
Adams at (202) 551-6902 or Irene Paik at (202) 551-6553 with any other


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cc:      Divakar Gupta